发给老马备查:, U( m/ f% ~% ^7 r+ G$ O5 ~' S
滴水察海(69304838) 15:23:23
7 B6 `( W b5 J8 Y$ w+ o3 ?老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
1 u/ e$ E2 H8 A! B: Z吉非替尼和S-1连用的依据
( L+ _- _$ \, nGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro. E3 G8 u' @# H- R8 K2 L
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达" I: J) g8 p# C1 z: U$ O' Z! _- E) n
这样是不是推理出,耐药后,可以用S-1和培美了?
# D5 c$ Q, i" V. x结论:5 S% r2 q: @2 H7 h7 Q
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |