发给老马备查:8 x, l+ N9 o& u+ r H
滴水察海(69304838) 15:23:23 / P+ v8 c n& s- t y老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱! w# `4 D: \2 B% I/ |! H
吉非替尼和S-1连用的依据 6 H$ {' @: X% ?Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.' V- f1 u- }3 K; v
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达, n; [; P' r, D/ F8 n; E+ t
这样是不是推理出,耐药后,可以用S-1和培美了?+ e+ [9 V1 T6 V% K6 ]
结论:. S& p1 y' w+ Q6 w4 v$ s8 n Z8 N. z
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。